| Event | Date | Location | |
| Preseason: Buffalo Bills vs Detroit Lions | Thu. Aug 28, 2008 6:30PM | Orchard Park, NY - Ralph Wilson Stadium |  |
| 2008 Buffalo Bills Season Tickets Package (Includes Tickets to All Regular Season Home Games) | Mon. Sep 1, 2008 TBA | Orchard Park, NY - Ralph Wilson Stadium | |
| Buffalo Bills vs Seattle Seahawks | Sun. Sep 7, 2008 1:00PM | Orchard Park, NY - Ralph Wilson Stadium | |
| Jacksonville Jaguars vs Buffalo Bills | Sun. Sep 14, 2008 1:00PM | Jacksonville, FL - Jacksonville Municipal Stadium | |
| Buffalo Bills vs Oakland Raiders | Sun. Sep 21, 2008 1:00PM | Orchard Park, NY - Ralph Wilson Stadium | |
| St. Louis Rams vs Buffalo Bills | Sun. Sep 28, 2008 3:05PM | Saint Louis, MO - Edward Jones Dome | |
| Arizona Cardinals vs Buffalo Bills | Sun. Oct 5, 2008 2:15PM | Glendale, AZ - University Of Phoenix Stadium | |
| Buffalo Bills vs San Diego Chargers | Sun. Oct 19, 2008 1:00PM | Orchard Park, NY - Ralph Wilson Stadium | |
| Miami Dolphins vs Buffalo Bills | Sun. Oct 26, 2008 1:00PM | Miami Gardens, FL - Dolphin Stadium | |
| Buffalo Bills vs New York Jets | Sun. Nov 2, 2008 1:00PM | Orchard Park, NY - Ralph Wilson Stadium | |
| New England Patriots vs Buffalo Bills | Sun. Nov 9, 2008 1:00PM | Foxboro, MA - Gillette Stadium | |
| Buffalo Bills vs Cleveland Browns | Mon. Nov 17, 2008 8:30PM | Orchard Park, NY - Ralph Wilson Stadium | |
| Kansas City Chiefs vs Buffalo Bills | Sun. Nov 23, 2008 12:00PM | Kansas City, MO - Arrowhead Stadium | |
| Buffalo Bills vs San Francisco 49ers | Sun. Nov 30, 2008 1:00PM | Orchard Park, NY - Ralph Wilson Stadium | |
| Buffalo Bills vs Miami Dolphins | Sun. Dec 7, 2008 1:00PM | Toronto, ON - Rogers Centre | |
| New York Jets vs Buffalo Bills | Sun. Dec 14, 2008 1:00PM | East Rutherford, NJ - Giants Stadium | |
| Denver Broncos vs Buffalo Bills | Sun. Dec 21, 2008 2:05PM | Denver, CO - Invesco Field At Mile High | |
| Buffalo Bills vs New England Patriots | Sun. Dec 28, 2008 1:00PM | Orchard Park, NY - Ralph Wilson Stadium | |
