| Event | Date | Location | |
| Houston Astros vs San Francisco Giants | Mon. Apr 5, 2010 TBA | Houston, TX - Minute Maid Park |  |
| Houston Astros vs San Francisco Giants | Tue. Apr 6, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs San Francisco Giants | Wed. Apr 7, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Philadelphia Phillies | Fri. Apr 9, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Philadelphia Phillies | Sat. Apr 10, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Philadelphia Phillies | Sun. Apr 11, 2010 TBA | Houston, TX - Minute Maid Park | |
| St. Louis Cardinals vs Houston Astros | Mon. Apr 12, 2010 3:15PM | Saint Louis, MO - Busch Stadium | |
| St. Louis Cardinals vs Houston Astros | Wed. Apr 14, 2010 7:15PM | Saint Louis, MO - Busch Stadium | |
| St. Louis Cardinals vs Houston Astros | Thu. Apr 15, 2010 12:40PM | Saint Louis, MO - Busch Stadium | |
| Chicago Cubs vs Houston Astros | Fri. Apr 16, 2010 TBA | Chicago, IL - Wrigley Field | |
| Chicago Cubs vs Houston Astros | Sat. Apr 17, 2010 TBA | Chicago, IL - Wrigley Field | |
| Chicago Cubs vs Houston Astros | Sun. Apr 18, 2010 TBA | Chicago, IL - Wrigley Field | |
| Houston Astros vs Florida Marlins | Tue. Apr 20, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Florida Marlins | Wed. Apr 21, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Florida Marlins | Thu. Apr 22, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Pittsburgh Pirates | Fri. Apr 23, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Pittsburgh Pirates | Sat. Apr 24, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Pittsburgh Pirates | Sun. Apr 25, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Cincinnati Reds | Tue. Apr 27, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Cincinnati Reds | Wed. Apr 28, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Cincinnati Reds | Thu. Apr 29, 2010 TBA | Houston, TX - Minute Maid Park | |
| Atlanta Braves vs Houston Astros | Fri. Apr 30, 2010 TBA | Atlanta, GA - Turner Field | |
| Atlanta Braves vs Houston Astros | Sat. May 1, 2010 TBA | Atlanta, GA - Turner Field | |
| Atlanta Braves vs Houston Astros | Sun. May 2, 2010 TBA | Atlanta, GA - Turner Field | |
| Houston Astros vs Arizona Diamondbacks | Mon. May 3, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Arizona Diamondbacks | Tue. May 4, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Arizona Diamondbacks | Wed. May 5, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Arizona Diamondbacks | Thu. May 6, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs San Diego Padres | Fri. May 7, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs San Diego Padres | Sat. May 8, 2010 TBA | Houston, TX - Minute Maid Park | |
