| Event | Date | Location | |
| Houston Astros vs Milwaukee Brewers | Wed. May 16, 2012 7:05PM | Houston, TX - Minute Maid Park |  |
| Houston Astros vs Milwaukee Brewers | Thu. May 17, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Texas Rangers | Fri. May 18, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Texas Rangers | Sat. May 19, 2012 6:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Texas Rangers | Sun. May 20, 2012 1:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Chicago Cubs | Mon. May 21, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Chicago Cubs | Tue. May 22, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Chicago Cubs | Wed. May 23, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Los Angeles Dodgers vs Houston Astros | Fri. May 25, 2012 7:10PM | Los Angeles, CA - Dodger Stadium | |
| Los Angeles Dodgers vs Houston Astros | Sat. May 26, 2012 7:10PM | Los Angeles, CA - Dodger Stadium | |
| Los Angeles Dodgers vs Houston Astros | Sun. May 27, 2012 1:10PM | Los Angeles, CA - Dodger Stadium | |
| Colorado Rockies vs Houston Astros | Mon. May 28, 2012 1:10PM | Denver, CO - Coors Field | |
| Colorado Rockies vs Houston Astros | Mon. May 28, 2012 6:10PM | Denver, CO - Coors Field | |
| Colorado Rockies vs Houston Astros | Wed. May 30, 2012 6:40PM | Denver, CO - Coors Field | |
| Colorado Rockies vs Houston Astros | Thu. May 31, 2012 6:40PM | Denver, CO - Coors Field | |
| Houston Astros vs Cincinnati Reds | Fri. Jun 1, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Cincinnati Reds | Sat. Jun 2, 2012 6:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Cincinnati Reds | Sun. Jun 3, 2012 1:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs St. Louis Cardinals | Tue. Jun 5, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs St. Louis Cardinals | Wed. Jun 6, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs St. Louis Cardinals | Thu. Jun 7, 2012 7:05PM | Houston, TX - Minute Maid Park | |
| Chicago White Sox vs Houston Astros | Fri. Jun 8, 2012 7:10PM | Chicago, IL - US Cellular Field | |
| Chicago White Sox vs Houston Astros | Sat. Jun 9, 2012 3:10PM | Chicago, IL - US Cellular Field | |
| Chicago White Sox vs Houston Astros | Sun. Jun 10, 2012 1:10PM | Chicago, IL - US Cellular Field | |
| San Francisco Giants vs Houston Astros | Tue. Jun 12, 2012 7:15PM | San Francisco, CA - AT&T Park | |
| San Francisco Giants vs Houston Astros | Wed. Jun 13, 2012 7:15PM | San Francisco, CA - AT&T Park | |
| San Francisco Giants vs Houston Astros | Thu. Jun 14, 2012 12:45PM | San Francisco, CA - AT&T Park | |
| Texas Rangers vs Houston Astros | Fri. Jun 15, 2012 7:05PM | Arlington, TX - Rangers Ballpark In Arlington | |
| Texas Rangers vs Houston Astros | Sat. Jun 16, 2012 6:15PM | Arlington, TX - Rangers Ballpark In Arlington | |
| Texas Rangers vs Houston Astros | Sun. Jun 17, 2012 2:05PM | Arlington, TX - Rangers Ballpark In Arlington | |