| Event | Date | Location | |
| Spring Training: Tampa Bay Rays vs Pittsburgh Pirates | Mon. Mar 8, 2010 1:05PM | Port Charlotte, FL - Charlotte County Stadium |  |
| Spring Training: Tampa Bay Rays vs Pittsburgh Pirates | Sun. Mar 28, 2010 1:05PM | Port Charlotte, FL - Charlotte County Stadium | |
| Pittsburgh Pirates vs Los Angeles Dodgers | Mon. Apr 5, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Los Angeles Dodgers | Wed. Apr 7, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Los Angeles Dodgers | Thu. Apr 8, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Arizona Diamondbacks vs Pittsburgh Pirates | Fri. Apr 9, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Pittsburgh Pirates | Sat. Apr 10, 2010 5:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Pittsburgh Pirates | Sun. Apr 11, 2010 1:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| San Francisco Giants vs Pittsburgh Pirates | Mon. Apr 12, 2010 7:15PM | San Francisco, CA - AT&T Park | |
| San Francisco Giants vs Pittsburgh Pirates | Tue. Apr 13, 2010 7:15PM | San Francisco, CA - AT&T Park | |
| San Francisco Giants vs Pittsburgh Pirates | Wed. Apr 14, 2010 12:00PM | San Francisco, CA - AT&T Park | |
| Pittsburgh Pirates vs Cincinnati Reds | Fri. Apr 16, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Cincinnati Reds | Sat. Apr 17, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Cincinnati Reds | Sun. Apr 18, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Milwaukee Brewers | Tue. Apr 20, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Milwaukee Brewers | Wed. Apr 21, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Milwaukee Brewers | Thu. Apr 22, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Houston Astros vs Pittsburgh Pirates | Fri. Apr 23, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Pittsburgh Pirates | Sat. Apr 24, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs Pittsburgh Pirates | Sun. Apr 25, 2010 TBA | Houston, TX - Minute Maid Park | |
| Milwaukee Brewers vs Pittsburgh Pirates | Mon. Apr 26, 2010 7:10PM | Milwaukee, WI - Miller Park | |
| Milwaukee Brewers vs Pittsburgh Pirates | Tue. Apr 27, 2010 7:10PM | Milwaukee, WI - Miller Park | |
| Milwaukee Brewers vs Pittsburgh Pirates | Wed. Apr 28, 2010 12:10PM | Milwaukee, WI - Miller Park | |
| Los Angeles Dodgers vs Pittsburgh Pirates | Thu. Apr 29, 2010 TBA | Los Angeles, CA - Dodger Stadium | |
| Los Angeles Dodgers vs Pittsburgh Pirates | Fri. Apr 30, 2010 TBA | Los Angeles, CA - Dodger Stadium | |
| Los Angeles Dodgers vs Pittsburgh Pirates | Sat. May 1, 2010 TBA | Los Angeles, CA - Dodger Stadium | |
| Los Angeles Dodgers vs Pittsburgh Pirates | Sun. May 2, 2010 TBA | Los Angeles, CA - Dodger Stadium | |
| Pittsburgh Pirates vs Chicago Cubs | Tue. May 4, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Chicago Cubs | Wed. May 5, 2010 TBA | Pittsburgh, PA - PNC Park | |
| Pittsburgh Pirates vs Chicago Cubs | Thu. May 6, 2010 TBA | Pittsburgh, PA - PNC Park | |
