| Event | Date | Location | |
| Arizona Diamondbacks vs San Diego Padres | Mon. Apr 5, 2010 2:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) |  |
| Arizona Diamondbacks vs San Diego Padres | Tue. Apr 6, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs San Diego Padres | Wed. Apr 7, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Colorado Rockies vs San Diego Padres | Fri. Apr 9, 2010 TBA | Denver, CO - Coors Field | |
| Colorado Rockies vs San Diego Padres | Sat. Apr 10, 2010 TBA | Denver, CO - Coors Field | |
| Colorado Rockies vs San Diego Padres | Sun. Apr 11, 2010 TBA | Denver, CO - Coors Field | |
| San Diego Padres vs Atlanta Braves | Mon. Apr 12, 2010 3:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Atlanta Braves | Wed. Apr 14, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Atlanta Braves | Thu. Apr 15, 2010 3:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Fri. Apr 16, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Sat. Apr 17, 2010 5:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Sun. Apr 18, 2010 1:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs San Francisco Giants | Mon. Apr 19, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs San Francisco Giants | Tue. Apr 20, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs San Francisco Giants | Wed. Apr 21, 2010 TBA | San Diego, CA - Petco Park | |
| Cincinnati Reds vs San Diego Padres | Fri. Apr 23, 2010 TBA | Cincinnati, OH - Great American Ball Park | |
| Cincinnati Reds vs San Diego Padres | Sat. Apr 24, 2010 TBA | Cincinnati, OH - Great American Ball Park | |
| Cincinnati Reds vs San Diego Padres | Sun. Apr 25, 2010 TBA | Cincinnati, OH - Great American Ball Park | |
| Florida Marlins vs San Diego Padres | Mon. Apr 26, 2010 TBA | Miami Gardens, FL - LandShark Stadium (Formerly Dolphin Stadium) | |
| Florida Marlins vs San Diego Padres | Tue. Apr 27, 2010 TBA | Miami Gardens, FL - LandShark Stadium (Formerly Dolphin Stadium) | |
| Florida Marlins vs San Diego Padres | Wed. Apr 28, 2010 TBA | Miami Gardens, FL - LandShark Stadium (Formerly Dolphin Stadium) | |
| San Diego Padres vs Milwaukee Brewers | Thu. Apr 29, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Milwaukee Brewers | Fri. Apr 30, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Milwaukee Brewers | Sat. May 1, 2010 5:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Milwaukee Brewers | Sun. May 2, 2010 1:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Colorado Rockies | Mon. May 3, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Colorado Rockies | Tue. May 4, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Colorado Rockies | Wed. May 5, 2010 7:05PM | San Diego, CA - Petco Park | |
| Houston Astros vs San Diego Padres | Fri. May 7, 2010 TBA | Houston, TX - Minute Maid Park | |
| Houston Astros vs San Diego Padres | Sat. May 8, 2010 TBA | Houston, TX - Minute Maid Park | |
